Last edited by Faera
Thursday, August 6, 2020 | History

3 edition of Drug-induced Hepatic Injury (Drug-Induced Disorders) found in the catalog.

Drug-induced Hepatic Injury (Drug-Induced Disorders)

by B. H. Ch. Stricker

  • 37 Want to read
  • 7 Currently reading

Published by Elsevier Science Publishing Company .
Written in English

    Subjects:
  • Pharmacology,
  • Gastroenterology,
  • Hepatology,
  • Medical research,
  • General,
  • Medical,
  • Medical / Nursing

  • The Physical Object
    FormatHardcover
    Number of Pages314
    ID Numbers
    Open LibraryOL9623466M
    ISBN 100444903429
    ISBN 109780444903426

    Dr. Zimmerman begins chapter 1 by stating that “Chemical injury to the liver is a many-faceted phenomenon” and then proceeds through 25 chapters to fill in the details. The first edition of this book, published in , was a milestone in defining the important emerging field of drug- and chemical-induced hepatotoxicity. Drug-induced liver injury is the most common cause of acute liver failure in the United States. Diagnosis of drug-induced liver injury is particularly challenging, since there are no specific biomarkers and it is based largely on exclusion of other causes of liver injury.

    Chitturi S, Teoh NC, Farrell GC. Hepatic drug metabolism and liver disease caused by drugs. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 10th ed. Philadelphia, PA: Elsevier Saunders; chap Devarbhavi H, Bonkovsky HL, Russo M, Chalasani N. Drug-induced liver injury.   Twenty‐four hours after tocilizumab administration, transaminase levels increased 40‐fold, suggesting a drug‐induced liver injury (DILI), but after 10 d, transaminase levels are almost normalized. At the same time CRP and IL‐6 levels (laboratory parameters associated with cytokine release syndrome) are approaching to the normal range.

      No book on liver disease can be complete without a discussion of the mechanisms of cell death, and here the current knowledge of apoptosis has provided much-needed insight into the induction of cell death by drugs. The roles of membrane transport and hepatotoxicity due to mitochondrial injury are also discussed. Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs. Chapter 30 is open access under a CC BY license via


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Drug-induced Hepatic Injury (Drug-Induced Disorders) by B. H. Ch. Stricker Download PDF EPUB FB2

Piperacillin is an extended-spectrum ureidopenicillin which, when combined with the beta-lactamase inhibitor tazobactam, is used to treat moderate-to-severe infectious due to susceptible organisms including lactamase producing penicillin-resistant bacteria.

Piperacillin-tazobactam has been linked with idiosyncratic liver injury, but only rarely and as isolated case reports. Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang H, Rochon J; Drug Induced Liver Injury Network (DILIN). Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States.

Gastroenterology ; [PMC free article: PMC] [PubMed: ]. Hepatotoxicity. Despite their wide use, omeprazole and esomeprazole have only rarely been associated with hepatic injury. In large scale, long term trials, serum ALT elevations occurred in less than 1% of patients and at rates similar to those that occurred with placebo or comparator drugs.

A small number of cases of clinically apparent liver disease due to omeprazole or esomeprazole have. Book chapter Full text access Chapter One - Primary hepatocytes and their cultures for the testing of drug-induced liver injury. Drug-Induced Liver Injury, Vol the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field.

Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI.

Drug-induced hepatic injury is of major concern to clinicians, pharmaceutical manufacturers, and regulators. Classic predisposing risk factors to drug-induced liver disease include age, race, and sex.

Additional factors of interest are the relationship between the dose of the drug and the extent of metabolism of an individual agent. Levofloxacin is a third generation fluoroquinolone that is widely used in the treatment of mild-to-moderate respiratory and urinary tract infections due to sensitive organisms.

Levofloxacin has been linked to rare instances of clinically apparent hepatic injury marked by a short latency period and a hepatocellular pattern of enzyme elevations, similar to what has been described with ciprofloxacin.

Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as an herbal for treatment of liver conditions. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver.

LiverTox ® provides up-to-date, unbiased and easily accessed information on the diagnosis, cause, frequency, clinical patterns and management of liver injury attributable to prescription and nonprescription medications and selected herbal and dietary supplements.

The LiverTox site is meant. Jay H. Hoofnagle, M.D., and Einar S. Björnsson, M.D. The liver has a range of responses to drug-induced injury, with a number of phenotypes.

In addition, idiosyncratic reactions may occur as a. Although drug‐induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality, leaving it as the leading cause of acute liver failure (ALF) in the United States.

It is one of the most challenging diagnoses encountered by gastroenterologists. DILI is also the most common single adverse event that has led to Cited by: 2. Hepatotoxicity is the injury or liver damage caused by exposure to drugs; it is an adverse drug reaction that may be uncommon but serious.

The hepatic injury can be classified into hepatocellular, cholestatic and mixed, caused by increase in alanine aminotransferase and alkaline phosphatase than upper limit of normal. The risk factors include idiosyncrasy, age, gender, alcohol. Drug-induced hepatic injury, which in earlier analysis seemed of relatively little moment, now appears to play a much more important role; hence the theme of this book is of great current importance.

Of particular recent interest have been the chronic lesions provoked by drug injury. Flucloxacillin is a common cause of drug-induced liver injury in Europe, affecting in the region of in everyfirst time users of the drug. The mechanism by which the drug causes the liver injury is currently unknown but it is believed to be influenced by a combination of.

Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical.

Adverse drug reactions (ADRs) are a common cause of attrition in drug discovery and development and drug-induced liver injury (DILI) is a leading cause of preclinical and clinical drug terminations. This perspective outlines many of the known DILI mechanisms and assessment methods used to evaluate and mitigate DILI risk.

Literature assessments and retrospective analyses using verified DILI. In the United States, drug-induced liver injury (DILI) is the most common cause of acute liver failure.

1,2 It can occur due to ingestion of any therapeutic drug, herbal product, or xenobiotic. Further complicating matters is the fact that it has an unpredictable and heterogeneous course, ranging from an asymptomatic rise in liver enzymes to. Drug induced liver injury is a leading cause of acute liver injury, of which acetaminophen (APAP) is the most frequent causative agent.

APAP toxicity is initiated by its toxic metabolite NAPQI. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more.

Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical. Malath Azeez Al-Saadi, in Dietary Interventions in Liver Disease, Abstract.

Liver injury has great importance, especially the drug-induced type. To assess the protective effects of vitamin D3 in a model of acetaminophen-induced acute hepatic injury, 18 male rabbits were assigned to three groups equally.

Chalasani N., Fontana R.J., Bonkovsky H.L. Drug induced liver injury network (DILIN). Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States.

Gastroenterology. ;– Verma S., Kaplowitz N. Diagnosis, management and prevention of drug-induced liver injury. Drug-induced liver injury in a COVID patient: potential interaction of remdesivir with P-glycoprotein inhibitors Emiel Leegwater, PharmD, Emiel Leegwater, PharmD.In this article, we are going to share with you drugs that cause hepatitis mnemonics so that you can easily remember all cases of drug-induced hepatitis for your exams.

But before we go to the mnemonics for drugs that cause hepatitis, let’s a look at the mechanism of hepatic drug metabolism.